SuppRankedTop 10 digestive supplements brands on Amazon (estimated revenue)
Ranked by estimated monthly revenue from Amazon's Digestive Supplements Best Sellers top 100. Updated October 15, 2026.
Physician's CHOICE is the top-selling digestive supplements brand on Amazon by estimated revenue, at about $3.7M/mo from 3 products in the Digestive Supplements Best Sellers top 100. That is about 22% more than #2 Metamucil (~$3M/mo). The list is fragmented: the top 3 brands take about 26% of its estimated sales and the top 10 about 60%, spread across 54 brands in total. The median list price in this top 100 is $22.70, and 31% of the products are gummies. All figures are modeled estimates, not Amazon data.
| # | Brand | Est. revenue/mo |
|---|---|---|
| 1 | Physician's CHOICE10% share · best #1 | $3.7M |
| 2 | Metamucil8% share · best #5 | $3M |
| 3 | Garden of Life8% share · best #2 | $2.8M |
| 4 | Seed7% share · best #6 | $2.5M |
| 5 | Align7% share · best #27 | $2.5M |
| 6 | Culturelle7% share · best #10 | $2.5M |
| 7 | Benefiber4% share · best #13 | $1.6M |
| 8 | Florastor4% share · best #17 | $1.6M |
| 9 | Lemme3% share · best #19 | $1.2M |
| 10 | ZBiotics2% share · best #16 | $909K |
The top 10, brand by brand
1. Physician's CHOICE
~$3.7M/mo est. revenue (10% of this list) and ~187K units/mo from 3 products; best position #1. Its highest-ranked product here is Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics… at #1. Overall it ranks #22 of 867 brands.
2. Metamucil
~$3M/mo est. revenue (8% of this list) and ~121K units/mo from 5 products; best position #5. Its highest-ranked product here is Metamucil Fiber Gummies for Adults, No Sugar Added Orange Flavor, 5g Prebiotic… at #5. Overall it ranks #20 of 867 brands.
3. Garden of Life
~$2.8M/mo est. revenue (8% of this list) and ~102K units/mo from 6 products; best position #2. Its highest-ranked product here is Garden of Life Dr. Formulated Once Daily Women's Probiotics, 50B CFU, 30ct | 50… at #2. Overall it ranks #9 of 867 brands.
4. Seed
~$2.5M/mo est. revenue (7% of this list) and ~42.1K units/mo from 1 product; best position #6. Its highest-ranked product here is Seed DS-01 Daily Synbiotic - Adult Probiotic + Prebiotic - 30-Days with Jar… at #6. Overall it ranks #104 of 867 brands.
5. Align
~$2.5M/mo est. revenue (7% of this list) and ~66.3K units/mo from 7 products; best position #27. Its highest-ranked product here is Align Probiotic, Pro Formula, Probiotics for Women and Men, Probiotics for… at #27. Overall it ranks #58 of 867 brands.
6. Culturelle
~$2.5M/mo est. revenue (7% of this list) and ~103K units/mo from 7 products; best position #10. Its highest-ranked product here is Culturelle Pro Strength Probiotics for Digestive Gut Health*, 12B CFU, 60ct… at #10. Overall it ranks #40 of 867 brands.
7. Benefiber
~$1.6M/mo est. revenue (4% of this list) and ~83.5K units/mo from 5 products; best position #13. Its highest-ranked product here is Benefiber Prebiotic Fiber Supplement Powder, Unflavored, 250 Teaspoons… at #13. Overall it ranks #50 of 867 brands.
8. Florastor
~$1.6M/mo est. revenue (4% of this list) and ~27.7K units/mo from 1 product; best position #17. Its highest-ranked product here is Florastor Probiotic for Digestive and Immune Health, 100 Capsules | Probiotics… at #17. Overall it ranks #148 of 867 brands.
9. Lemme
~$1.2M/mo est. revenue (3% of this list) and ~39.6K units/mo from 2 products; best position #19. Its highest-ranked product here is Lemme Purr Vaginal Probiotic Gummies for Women, 30-Day Supply | Balanced pH… at #19. Overall it ranks #28 of 867 brands.
10. ZBiotics
~$909K/mo est. revenue (2% of this list) and ~25.2K units/mo from 1 product; best position #16. Its highest-ranked product here is ZBiotics Pre-Alcohol Probiotic — Drink Responsibly, for an Easier Tomorrow at #16. Overall it ranks #166 of 867 brands.
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Full Digestive Supplements ranking
All 54 brands in the list, ordered by rank strength, plus the top 10 products.
See all Digestive Supplements brands →