SuppRankedTop 10 enzymes brands on Amazon (estimated revenue)
Ranked by estimated monthly revenue from Amazon's Enzymes Best Sellers top 100. Updated October 15, 2026.
Physician's CHOICE is the top-selling enzymes brand on Amazon by estimated revenue, at about $2.6M/mo from 3 products in the Enzymes Best Sellers top 100. That is about 3.1× as much as #2 NOW Foods (~$831K/mo). The list is fairly concentrated: the top 3 brands take about 37% of its estimated sales and the top 10 about 66%, spread across 52 brands in total. All figures are modeled estimates, not Amazon data.
| # | Brand | Est. revenue/mo |
|---|---|---|
| 1 | Physician's CHOICE23% share · best #1 | $2.6M |
| 2 | NOW Foods7% share · best #5 | $831K |
| 3 | Pure Encapsulations7% share · best #8 | $788K |
| 4 | Enzymedica7% share · best #4 | $785K |
| 5 | Micro Ingredients5% share · best #7 | $555K |
| 6 | FODZYME5% share · best #14 | $544K |
| 7 | Zenwise4% share · best #2 | $466K |
| 8 | Dr. Berg3% share · best #15 | $386K |
| 9 | Nutricost3% share · best #23 | $304K |
| 10 | Doctor's Best2% share · best #10 | $281K |
The top 10, brand by brand
1. Physician's CHOICE
~$2.6M/mo est. revenue (23% of this list) and ~96.5K units/mo from 3 products; best position #1. Its highest-ranked product here is Physician's CHOICE Digestive Enzymes for Bloating & Digestion - Fast-Acting 16… at #1. Overall it ranks #26 of 3,479 brands.
2. NOW Foods
~$831K/mo est. revenue (7% of this list) and ~37.5K units/mo from 8 products; best position #5. Its highest-ranked product here is Now Foods Super Enzymes, 180 Capsules at #5. Overall it ranks #1 of 3,479 brands.
3. Pure Encapsulations
~$788K/mo est. revenue (7% of this list) and ~19K units/mo from 5 products; best position #8. Its highest-ranked product here is Pure Encapsulations Digestive Enzymes Ultra, 90 Capsules | Vegetarian Digestive… at #8. Overall it ranks #4 of 3,479 brands.
4. Enzymedica
~$785K/mo est. revenue (7% of this list) and ~25.2K units/mo from 9 products; best position #4. Its highest-ranked product here is Enzymedica Digest Gold, Maximum Strength, ATPro Energy Support - 90 Caps… at #4. Overall it ranks #122 of 3,479 brands.
5. Micro Ingredients
~$555K/mo est. revenue (5% of this list) and ~19.1K units/mo from 3 products; best position #7. Its highest-ranked product here is Micro Ingredients Nattokinase 10,000 FU Per Serving, 240 Veggie Capsules… at #7. Overall it ranks #9 of 3,479 brands.
6. FODZYME
~$544K/mo est. revenue (5% of this list) and ~7.2K units/mo from 1 product; best position #14. Its highest-ranked product here is FODZYME® Home Kit Digestive Enzymes for Gut Health, Relief for Bloating, Gas… at #14. Overall it ranks #559 of 3,479 brands.
7. Zenwise
~$466K/mo est. revenue (4% of this list) and ~16.9K units/mo from 2 products; best position #2. Its highest-ranked product here is Zenwise Health Digestive Enzymes, Probiotics, for Gut Health Bloat - 180 CT… at #2. Overall it ranks #225 of 3,479 brands.
8. Dr. Berg
~$386K/mo est. revenue (3% of this list) and ~11K units/mo from 2 products; best position #15. Its highest-ranked product here is Dr. Berg Gallbladder Formula Extra Strength - with Ox Bile Powder and… at #15. Overall it ranks #24 of 3,479 brands.
9. Nutricost
~$304K/mo est. revenue (3% of this list) and ~15.2K units/mo from 4 products; best position #23. Its highest-ranked product here is Nutricost Bromelain (500mg) 120 Vegetarian Capsules, Gluten Free | Bromelain… at #23. Overall it ranks #2 of 3,479 brands.
10. Doctor's Best
~$281K/mo est. revenue (2% of this list) and ~9.5K units/mo from 4 products; best position #10. Its highest-ranked product here is Doctor's Best Nattokinase 2000 FU Supplement, for Men & Women, 270 Veg Caps… at #10. Overall it ranks #29 of 3,479 brands.
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Full Enzymes ranking
All 52 brands in the list, ordered by rank strength, plus the top 10 products.
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